Accumulation of D-Aspartic Acid with Age in the Human Brain
- 24 June 1983
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 220 (4604), 1407-1408
- https://doi.org/10.1126/science.6857259
Abstract
An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.Keywords
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