Ticarcillin: Pharmacokinetics in Man According to Different Administration Schedules
- 1 September 1977
- journal article
- research article
- Published by SAGE Publications in Journal of International Medical Research
- Vol. 5 (5), 308-312
- https://doi.org/10.1177/030006057700500504
Abstract
The pharmacokinetic characteristics of ticarcillin, a semisynthetic penicillin more active than carbenicillin against Pseudomonas, were studied. Following a rapid intravenous infusion of 1 g, 2 g, 5 g and 10 g ticarcillin respectively the serum half-life was 72·4 minutes independent of the dosage administered. If ticarcillin is administered under steady-state conditions, e.g. continuous infusion of either 2 g/hr or 1 g/hr following a loading dose of 1 g (total dose 5 g) the average steady-state serum concentrations are 125 μg/ml and 105 μg/ml respectively.This publication has 16 references indexed in Scilit:
- In Vitro Activity of Ticarcillin Against Anaerobic Bacteria Compared with That of Carbenicillin and PenicillinAntimicrobial Agents and Chemotherapy, 1977
- Pharmacokinetics of Amoxycillin According to Administration ScheduleJournal of International Medical Research, 1976
- Comparative In Vitro Activity and Clinical Pharmacology of Ticarcillin and CarbenicillinAntimicrobial Agents and Chemotherapy, 1975
- Ticarcillin vs carbenicillin: Clinical pharmacokineticsClinical Pharmacology & Therapeutics, 1975
- A Comparative Experimental Study of the Circulation of Amoxycillin and Penicillin G in the Cerebro-Spinal Fluid of Dogs as a Function of the Type of Intravenous AdministrationJournal of International Medical Research, 1974
- Activity of carbenicillin and ticarcillin against pseudomonas aeruginosa compared by paired in vitro testsInfection, 1974
- Zur Pharmakokinetik des Carbenicillins bei hoher DosierungDeutsche Medizinische Wochenschrift (1946), 1974
- Clinical Pharmacology of Ticarcillin (α-Carboxyl-3-Thienylmethyl Penicillin, BRL-2288)Antimicrobial Agents and Chemotherapy, 1973
- Advances in the management of Pseudomonas aeruginosa infections in cancer patientsEuropean Journal of Cancer (1965), 1973
- Semisynthetic PenicillinsPublished by Elsevier ,1973