Ethanol Inhibition of Vitamin A Metabolism in the Testes: Possible Mechanism for Sterility in Alcoholics
- 6 December 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4167), 941-942
- https://doi.org/10.1126/science.186.4167.941
Abstract
Vitanin A (retinol) is essential for spermatogenesis. Alcohol dehydrogenase, the enzyme responsible for ethanol metabolism, is also required for the conversion of retinol to bioactive retinal at the end organ site. Ethanol inhibits the oxidation of retinol by testicular homogenates containing alcohol dehydrogenase. Thus, a possible biochemnical mechanism for the sterility of chronic alcoholics is identified.Keywords
This publication has 9 references indexed in Scilit:
- The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retinaExperimental and Molecular Pathology, 1971
- Stimulatory effect of vitamins and glutamine on the differentiation of germ cells in rat testes organ culture grown in chemically defined mediaExperimental Cell Research, 1966
- [78] Liver alcohol dehydrogenaseMethods in Enzymology, 1955
- The Testis, Breast and Prostate of Men Who Die of Cirrhosis of The LiverAmerican Journal of Clinical Pathology, 1950
- Endocrine changes associated with Laennec's cirrhosis of the liverAmerican Journal Of Medicine, 1948
- HEPATIC CIRRHOSIS AND TESTICULAR ATROPHYArchives of Internal Medicine, 1947
- THE OCCURRENCE OF ABNORMAL DARK ADAPTATION AND ITS RELATION TO VITAMIN A METABOLISM IN PATIENTS WITH CIRRHOSIS OF THE LIVERJCI Insight, 1939
- THE PHARMACOLOGY AND THERAPEUTICS OF VITAMIN AJAMA, 1938
- TESTICULAR DEGENERATION DUE TO INADEQUATE VITAMIN A IN CASES WHERE E IS ADEQUATEAmerican Journal of Physiology-Legacy Content, 1932