A dimerization-dependent mechanism drives RAF catalytic activation
Top Cited Papers
- 2 September 2009
- journal article
- Published by Springer Nature in Nature
- Vol. 461 (7263), 542-545
- https://doi.org/10.1038/nature08314
Abstract
Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.Keywords
This publication has 25 references indexed in Scilit:
- Potent and selective pyrazole-based inhibitors of B-Raf kinaseBioorganic & Medicinal Chemistry Letters, 2008
- Therapeutic strategies for inhibiting oncogenic BRAF signalingCurrent Opinion in Pharmacology, 2008
- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activityProceedings of the National Academy of Sciences, 2008
- Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerOncogene, 2007
- CK2 Is a Component of the KSR1 Scaffold Complex that Contributes to Raf Kinase ActivationCurrent Biology, 2007
- Emerging roles of pseudokinasesTrends in Cell Biology, 2006
- Wild-Type and Mutant B-RAF Activate C-RAF through Distinct Mechanisms Involving HeterodimerizationMolecular Cell, 2005
- Coordinating ERK/MAPK signalling through scaffolds and inhibitorsNature Reviews Molecular Cell Biology, 2005
- The Protein Kinase Complement of the Human GenomeScience, 2002
- Mutations of the BRAF gene in human cancerNature, 2002