The relationship between t and H-2 complexes in wild mice: I. The H-2 haplotypes of 20 t-bearing strains

Abstract

SUMMARY: Twenty t haplotypes were extracted from wild mice captured at several locations in Europe, Israel, North Africa, and South America. The haplotypes were designated t^Tuw1 through t^Tuw20. The H-2 haplotypes of the lines were defined using antisera and monoclonal antibodies specific for private antigenic determinants controlled by known H-2 alleles and by antisera produced using the new t lines as donors. The t^Tuw haplotypes fall into four groups according to the H-2 haplotype associated with them. Haplotypes t^Tuw10 through t^Tuw18 are associated with H-2^W30, previously found to be linked with haplotypes of the t^w1 group. Haplotypes t^Tuw1 through t^Tuw6 are associated with a new H-2 haplotype, H-2^w36, characterized by the determinant H-2.107. Haplotypes t^Tuw7 through t^Tuw9 are associated with another new H-2 haplotype, H-2^w37, characterized by determinants H-2.108 and H-2.111. And finally, haplotypes t^Tuw19 and t^Tuw20 are associated with yet another new H-2 haplotype, H-2^w38, characterized by determinants H-2.33 and H-2.109. These findings suggest that the t polymorphism might be more extensive and more intricate than it was previously thought to be and that at least some of the t-associated H-2 haplotypes, and probably also the t haplotypes themselves, are related to one another in their origin.