The determination of bupivacaine, lignocaine and mepivacaine in human blood
- 1 September 1968
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 20 (9), 704-708
- https://doi.org/10.1111/j.2042-7158.1968.tb09841.x
Abstract
A specific method for the quantitative analysis of bupivacaine, lignocaine and mepivacaine in blood, in clinically occurring concentrations, using gas-liquid chromatography, is described. The extraction procedure yields a recovery of 97·5 (±5)%, and the chromatographic conditions allow concentrations as low as 0·04 μg/ml of local anaesthetic in 2 ml of whole blood to be measured. The method has a standard deviation of 5·4%. No interference is encountered from commonly used premedicant or general anaesthetic drugs.Keywords
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