Synthetic Studies of Hydronaphthacenic Antibiotics. I. The Synthesis of 4-Demethoxy-7-O-methyl Daunomycinone

Abstract

Daunomycin is a new and very promising antitumor antibiotic. This communication reports the synthesis of (dl)-4-demethoxy-7-O-methyl daunomycinone as part of a scheme toward the total synthesis of daunomycin.