Effects of Aspirin and Dextran on Patency of Bovine Heterografts in the Venous System

Abstract

The effect of short-term treatment with aspirin or dextran on the patency of bovine heterografts in the venous system was investigated. Animals treated preoperatively and for 3 days postoperatively with either aspirin (600 mg 2 times daily) or low MW dextran (500 ml/day) had statistically significant increased graft patency as compared to controls during treatment interval. Significance was lost, after cessation of therapy. Either aspirin or low MW dextran is a useful adjuvant to venous reconstruction. If used in the venous system, bovine heterografts might be expected to yield better short term patency with adjuvant therapy employing either dextran or aspirin.