Emperipolesis of Hematopoietic Cells within Megakaryocytes in Bone Marrow of the Rat
Open Access
- 1 November 1989
- journal article
- research article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 26 (6), 473-478
- https://doi.org/10.1177/030098588902600603
Abstract
Emperipolesis of hematopoietic cells within megakaryocytes was found in rats. The incidence was less than 0.3% in young rats (2 to 12 months old) but increased to 2–5% among the aging rats (18 to 24 months old). The incidence increased markedly in hyperplastic bone marrow secondary to chronic suppurative or neoplastic lesions. Mature neutrophils appeared to be the most common marrow cell engulfed by megakaryocytes. By light microscopy, engulfed cells were separated from megakaryocyte cytoplasm by a narrow pericellular space. By electron microscopy, marrow cells engulfed by megakaryocytes were located in the open canalicular system. Cell membranes of both engulfed cells and megakaryocytes were intact, and there was no fusion of cell membranes or phagosome formation in the megakaryocytes.Keywords
This publication has 9 references indexed in Scilit:
- EMPERIPOLESIS OF GRANULOCYTES WITHIN MEGAKARYOCYTESBritish Journal of Haematology, 1985
- Emperipolesis — a peculiar feature of megakaryocytes as evaluated in chronic myeloproliferative diseases by morphometry and ultrastructureVirchows Archiv B Cell Pathology Including Molecular Pathology, 1984
- Emperipolesis of neutrophils by dysmorphic megakaryocytesAmerican Journal of Hematology, 1982
- Dynamics of Red Cell Egress from Bone Marrow after Blood LettingBritish Journal of Haematology, 1981
- ON THE ALLEGED DIAGNOSTIC SIGNIFICANCE OF MEGAKARYOCYTIC ‘PHAGOCYTOSIS’ (EMPERIPOLESIS)British Journal of Haematology, 1981
- Marrow Cell Uptake by Megakaryocytes in Routine Bone Marrow Smears during Blood LossScandinavian Journal of Haematology, 1976
- Emperipolesis of Granular Leukocytes within Megakaryocytes in Human Hemopoietic Bone MarrowAmerican Journal of Clinical Pathology, 1970
- Biological Interaction Between Lymphocytes and. Other CellsBritish Journal of Haematology, 1956