THE MOTOR AND SECRETORY ACTIVITY OF THE STOMACH DURING ACUTE AND CHRONIC OBSTRUCTIVE JAUNDICE IN DOGS

Abstract

Gastric motility was studied on gastrostomy dogs by the balloon method. Gastric secretion was studied on Pavlov pouch dogs. Collections of the continuous secretion and the secretion following a standard test meal were made. Acute jaundice was produced by the injection of dog bile following suitable control experiments. Chronic obstructive jaundice was produced by double ligation and section of the common bile duct. Intravenous injection of [image] cc. of bladder bile per kgm. of body weight in dogs causes an immediate but temporary inhibition of gastric motility (hunger), and greatly diminishes the gastric secretion following a test meal. Chronic obstructive jaundice is followed by a decrease of the motor activity of the empty stomach, a decreased rate of gastric juice secretion, and an increased acidity of the gastric juice.