To the Editor:— InThe Journalof Feb. 26, 1955, page 751, Dr. Henry I. Russek has indicated that according to his method of evaluating drugs for the treatment of the anginal syndrome, choline theophyllinate is not of any value. I wish to take exception to his method of studying such agents, since it is dependent entirely upon certain subjects who have a sensitive electrocardiographic configuration, which may or may not respond to certain drugs. Such a technique is reminiscent of a similar procedure recommended many years ago for the human assay of digitalis or its glycosides. Here again, reliance on sensitive subjects did not reflect the clinical usefulness of any of the digitalis preparations. If one was to conclude from the digitalis studies that a particular preparation was not effective because it did not change the electrocardiogram, the majority of patients would not be treated by this valuable drug.