MECHANICAL RESPONSES OF RAT ISOLATED UTERINE HORNS TO TRANSMURAL STIMULATION
Open Access
- 1 September 1975
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 55 (1), 41-46
- https://doi.org/10.1111/j.1476-5381.1975.tb07607.x
Abstract
1 Transmural stimulation of rat isolated uterine horns at low pulse width produced contractions. These were antagonized by hyoscine or tetrodotoxin and potentiated by physostigmine. 2 In the presence of hyoscine, and during bradykinin-induced contractions, transmural stimulation produced inhibition. This inhibition was antagonized by guanethidine, propranolol or tetrodotoxin. 3 Hexamethonium or pempidine did not affect responses to transmural stimulation. 4 It is suggested that transmural stimulation is a method of exciting cholinergic motor and noradrenergic inhibitory postganglionic neurones to the rat myometrium.Keywords
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