Serum Concentrations of γG, γA, and γM Immunoglobulins in Patients With Carcinoma, Melanoma, and Sarcoma

Abstract

The concentrations of γG, γA, and γM immunoglobulins in sera from 256 normal controls were compared with those from 984 patients with cancer of nonhematopoietic tissues. Male patients with carcinoma of the skin and lung had significantly increased γG and γA concentrations. γA was significantly increased in patients with cancer of the mouth, gut, and uterus, the ratio of the γA concentration to that of γG being significantly increased. Serum γM concentrations were significantly increased in male patients with sarcoma and in female patients with melanoma. Patients with primary ovarian cancer had a significantly lower than normal γM concentration. Normal females had a significantly higher γM concentration than normal males. In both normal controls and cancer patients, males had significantly higher concentrations of γA than females.