Late changes in the architecture of blood vessels of the rat brain after irradiation

Abstract
The development of vascular changes in the rat brain after a moderate dose of X-rays (2000 cGy (rad)) was investigated by an angiographic method. Even with a dose 2000 cGy a gradual development of vascular abnormalities occurs; these develop between 12 and 14 mo. after irradiation. Focal telangiectasis in the parts containing white matter is the earliest sign that can be detected with the method employed.