The Suppression of Pineal Melatonin Content andN-AcetyItransferase Activity by Different Light Irradiances in the Syrian Hamster: A Dose-Response Relationship*
- 1 July 1983
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 113 (1), 293-296
- https://doi.org/10.1210/endo-113-1-293
Abstract
The purpose of this study was to test the influence of various irradiances of cool white fluorescent light on the suppression of pineal N-acetyltransferase activity (NAT) and melatonin content in hamsters. Groups of animals were exposed to light irradiances ranging from 0.00–1.86 microwatts (μW)/ cm2 for 20 min during the night. Both pineal NAT and melatonin were similarly depressed by the light irradiances in a dose-related manner. The shape of the resultant dose-response curves and the calculated ED50 for NAT (0.066 μW/cm2) and melatonin (0.058 μW/cm2) were remarkably similar. These findings may be relevant to the physiological control of the pineal by natural illumination. (Endocrinology113: 293, 1983)Keywords
This publication has 3 references indexed in Scilit:
- The effect of different light intensities on pineal melatonin contentBrain Research, 1982
- Light Intensity and the Control of Melatonin Secretion in RatsNeuroendocrinology, 1981
- Quantification of Daily Melatonin Synthesis in the Hamster Pineal Gland*Endocrinology, 1980