Acute Granulocytic Leukemia after Radioactive-Iodine Therapy for Hyperthyroidism

Abstract

FIVE cases of acute leukemia after radioactive-iodine (I¹³¹) therapy of hyperthyroidism have been reported.^{1 2 3 4} It has been assumed that the frequency of acute leukemia associated with I¹³¹ therapy for this disease corresponds to the expected spontaneous occurrence in the general population. Werner and Quimby,⁴ in reporting a case of acute leukemia after I¹³¹ therapy for hyperthyroidism, note that the addition of their case to those previously reviewed in a recent conference on radioiodine sponsored by the Argonne Cancer Research Hospital, United States Atomic Energy Commission, and the Clinics of the University of Chicago³ resulted in an incidence of 1 . . .