CALCIUM-ANTAGONISTS AND ISLET FUNCTION .10. EFFECT OF SULOCTIDIL

Abstract

Suloctidil (0.5-5.0 .mu.M) inhibits insulin release evoked by glucose or .alpha.-ketoisocaproate in pancreatic islets. The drug inhibits basal and glucose-stimulated 45Ca net uptake by the islets. In an artificial system, suloctidil inhibits A23187 [(Ca ionophore) 2-[3.beta.,9.alpha.,11.beta.-trimethyl)-1,7-dioxaspiro[6.6]undecyl-2.beta.-methyl]-5-methylaminobenzoxazole-4-carboxylic acid] mediated Ca translocation. The inhibitory action of suloctidil upon islet function may be due to interference with B-cell native ionophoretic system(s).