Aryl hydrocarbon hydroxylase and 16?-hydroxylase in cultured human lymphocytes
- 1 August 1976
- journal article
- research article
- Published by Springer Nature in Biochemical Genetics
- Vol. 14 (7-8), 671-685
- https://doi.org/10.1007/bf00485845
Abstract
Aryl hydrocarbon hydroxylase and 16α-hydroxylase were examined in intact, cultured human lymphocytes. The two microsomal mixed-function oxygenases had different pH optima and showed competitive inhibition for enzyme induction and activity. Population distributions were lognormal for both enzymes, giving apparent evidence for polygenic control. Induced levels of AHH were slightly higher among first-order relatives of lung or colon cancer patients than in the control group. The correlation coefficient (r) for AHH and SAH co-inducibility was −0.08, indicating no correlation and suggesting the absence of association between the two enzymes in man.Keywords
This publication has 60 references indexed in Scilit:
- Metabolism of diphenyloxazole (PPO) by mouse liver microsomesLife Sciences, 1975
- Sequential stimulation of synthesis of two specific cytoplasmic proteins in early estrogen actionBiochemical and Biophysical Research Communications, 1975
- Binding of 5S estradiol receptor to poly-deoxynucleotidesBiochemical and Biophysical Research Communications, 1974
- 3-Methylcholanthrene-inducible binding of aromatic hydrocarbons to DNA in purified rat liver nucleiBiochemical and Biophysical Research Communications, 1974
- Isolation and characterization of an active DNA-binding metabolite of benzo(a)pyrene from hamster liver microsomal incubation systemsBiochemical and Biophysical Research Communications, 1972
- Some problems in Michaelis-Menten kinetic analysis of benzpyrene hydroxylase in hepatic microsomes from polycyclic hydrocarbon-pretreated animalsChemico-Biological Interactions, 1972
- Estrophile to nucleophile in two easy stepsJournal of Steroid Biochemistry, 1972
- Genetic predisposition to carcinoma of the breast: Multiple human genotypes for estrogen 16 alpha hydroxylase activity in caucasiansJournal of Surgical Oncology, 1972
- FACTORS AFFECTING DRUG METABOLISMAnnals of the New York Academy of Sciences, 1971
- Mechanisms of Oxygen MetabolismPublished by Wiley ,1957