A series of strokes suffered by a 50-year-old woman were interpreted clinically as being on an arteriosclerotic basis but at autopsy proved to have been caused by emboli of chorion-epithelloma. The patient had undergone hysterectomy for hydatidiform mole one and one-half years before the onset of her neurological problems. Autopsy failed to reveal any residual tumor in the pelvis. This case demonstrates an unusual ingravescence of an ordinarily highly malignant neoplasm and a misleading purely neurological terminal recrudescence. It also points up the danger of interpreting too conservatively the potential malignancy of uterine moles and importance of long-term follow-up.