The extent of pancreatectomy for the treatment of nesidioblastosis is open to dispute. Recurrent hypoglycaemia, insulin-dependent diabetes mellitus, or exocrine insufficiency may result. 1) A female twin presented with hypoglycaemia, insulin response inappropriate for glucose levels, marked leucine sensitivity, low ketones, underwent 7/8 pancreatectomy for multifocal adenomatosis at the age of 13 months. 2) A boy of 7 months of age had a 95% resection including the uncinate process. Focal adenomatosis combined with diffuse nesidioblastosis proved by immunohistological examination. Both remained asymptomatic and normoglycaemic. The prognosis seems to depend on the primary extent of resection.