Role of Cholate in Dietary-Induced Hypercholesteremia of Rats and Rabbits

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Abstract
The present studies confirmed the finding that marked chronic hypercholesteremia without atherosclerosis occurs in rats simultaneously fed cholesterol and cholate. The hypercholesteremia produced in rats and rabbits fed cholesterol, cholate or both together is independent of the plasma cholate concn. It was concluded that dietary-induced hypercholesteremia as well as the augmentative effect of feeding cholate are independent of the known "intravascular" ability of cholate to induce hypercholesteremia.