The impact of birth weight on prostate cancer incidence and mortality in a population‐based study of men born in 1913 and followed up from 50 to 85 years of age
- 14 June 2007
- journal article
- research article
- Published by Wiley in The Prostate
- Vol. 67 (11), 1247-1254
- https://doi.org/10.1002/pros.20428
Abstract
BACKGROUND Insulin-like growth factor-I (IGF-I) hormone is directly associated with birth weight (BW), and high IGF-I measured in adults is associated with increased risk of prostate cancer (PCA). Whether BW and PCA are related is inconclusive to date. METHODS BW and PCA incidence and mortality data for a population-based cohort of 1,436 singleton Swedish men born in 1913 and followed until 85 years of age were obtained. RESULTS BW ≥ 4,250 g was associated with significantly higher PCA incidence [62% (CI: 4%–151%)] and PCA mortality [82% (CI: 3%–221%)] than BW 3,001–4,249 g, even when other potential effect modifiers were taken into account. The hazards ratio for PCA incidence fell from approximately 3 at age 50 to unity at age 85. Approximately one out of every six PCA incident cases between 50 and 70 years of age could be attributed to BW ≥ 4,250 g. CONCLUSIONS In the current study PCA incidence and mortality rate appears to increase with BW. Prostate 67: 1247–1254, 2007.Keywords
This publication has 49 references indexed in Scilit:
- Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-yearsInternational Journal of Epidemiology, 2005
- The impact of birth weight on coronary heart disease morbidity and mortality in a birth cohort followed up for 85 years: a population‐based study of men born in 1913Journal of Internal Medicine, 2004
- Size at birth and risk of breast cancer: Prospective population‐based studyInternational Journal of Cancer, 2004
- Birth size and subsequent risk for prostate cancer: A prospective population-based study in NorwayInternational Journal of Cancer, 2004
- Early growth, adult body size and prostate cancer riskInternational Journal of Cancer, 2002
- Birth Size and Neonatal Levels of Major Components of the IGF System: Implications for Later Risk of CancerJournal of Pediatric Endocrinology and Metabolism, 2002
- Would prostate cancer detected by screening withprostate-specific antigen develop into clinical cancer if left undiagnosed? A comparison of two population-based studies in SwedenBJU International, 2000
- Childhood leg length and adult mortality: follow up of the Carnegie (Boyd Orr) Survey of Diet and Health in Pre-war BritainJournal of Epidemiology and Community Health, 1998
- Size at birth and plasma insulin-like growth factor-1 concentrations.Archives of Disease in Childhood, 1995
- High Birthweight as a Predictor of Prostate Cancer RiskEpidemiology, 1995