Multipin solid‐phase synthesis of acyl 2,3‐diaminopropionic acid oligomers
- 1 May 1996
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 47 (5), 414-418
- https://doi.org/10.1111/j.1399-3011.1996.tb01091.x
Abstract
A modular approach for the synthesis of sets of diverse organic molecules is described. N-alpha-Fmoc-N-beta-Alloc-D-2,3-diaminopropionic acid (Fmoc-D-Dpr(Alloc)-OH) was prepared in four steps from Boc-D-asparagine and used as a scaffold for attachment of sidechains. Using the Multipin approach, a number of model acyl trimers were rapidly prepared by sequential coupling of Fmoc-D-Dpr(Alloc)-OH and acylation of the beta-amino group with a range of activated carboxylic acids.Keywords
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