Circulating Antibody Formation in Scorbutic Guinea Pigs

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Abstract
Severe scurvy was induced in young guinea pigs by feeding a highly purified ascorbic acid-deficient diet. After immunization with diphtheria toxoid, no deleterious effects on primary or secondary circulating antibody formation were observed in these scorbutic guinea pigs. A reduction in the early, Arthus-type, dermal hypersensitivity observed in the immunized scorbutic guinea pigs did not appear to be immunological in nature.