Parenteral Penicillin in Rats: An Experimental Model of Multifocal Epilepsy
- 1 June 1976
- Vol. 17 (2), 217-222
- https://doi.org/10.1111/j.1528-1157.1976.tb03399.x
Abstract
Parenterally injected penicillin in rats induced a peculiar pattern of multifocal epilepsy. The effective amount was higher than that required in cats. The epileptiform activity initially appeared on the cortical mantle of 1 hemisphere; after a variable delay, contralateral cortical spikes arose in a completely asynchronous way. Spontaneous independent firing was observed with a further delay in subcortical structures. Although cortical spiking showed a tendency to become bilaterally synchronous, such synchrony was only occasionally observed between the various subcortical structures. Formation of generalized spike-and-wave complexes, as reported in cats, or other features reminiscent of the human petit mal did not occur. There are differences in pathophysiological responses to the same epileptogenic model according to species variation.Keywords
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