Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates
- 31 October 1988
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 62 (11), 4414-4419
- https://doi.org/10.1128/jvi.62.11.4414-4419.1988
Abstract
According to their capacity to replicate in vitro, human immunodeficiency virus (HIV) isolates can be divided into two major groups, rapid/high and slow/low. Rapid/high viruses can easily be transmitted to a variety of cell lines of T-lymphoid (CEM, H9, and Jurkat) and monocytoid (U937) origin. In contrast, slow/low viruses replicate transiently, if at all, in these cell lines. Except for a few isolates, the great majority of slow/low viruses replicate in peripheral blood mononuclear cells and Junkat-tatIII cells constitutively expressing the tatIII gene of HIV-1. The viruses able to replicate efficiently cause syncytium formation and are regularly isolated from immunodeficient patients. Poorly replicating HIV isolates, often obtained from individuals with no or mild disease, show syncytium formation and single-cell killing simultaneously or, with some isolates, cell killing only.This publication has 22 references indexed in Scilit:
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