Elevation of brain neuroleptic/dopamine receptors in schizophrenia
- 1 February 1980
- journal article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 137 (2), 191-197
- https://doi.org/10.1176/ajp.137.2.191
Abstract
To test the dopamine hypothesis of schizophrenia the authors measured specific 3H-neuroleptic/dopamine binding sites in three dopamin-rich regions of 59 postmortem normal human brains and 50 postmortem brains from schizophrenic patients using 3H-haloperidol and 3H-spiperone. The binding of 2 nM 3H-haloperidol and of 1 nM 3H-spiperone was significantly elevated in the brains from schizophrenic patients. The brain regions from patients who had no history of being treated with neuroleptic drugs also exhibited significantly higher binding of the 3H-neuroleptics. These results are compatible with the hypothesis that schizophrenia may be associated with an overactivity of postsynaptic dopamine receptors.Keywords
This publication has 33 references indexed in Scilit:
- Selective labeling of different dopamine receptors by a new agonist 3H-ligand: 3H-N-propylnorapomorphineEuropean Journal of Pharmacology, 1979
- Similar binding of 3H-ADTN and 3H-apomorphine to calf brain dopamine receptorsEuropean Journal of Pharmacology, 1979
- 3H-spiroperidol labels serotonin receptors in rat cerebral cortex and hippocampusEuropean Journal of Pharmacology, 1978
- Spiperone: A ligand of choice for neuroleptic receptorsBiochemical Pharmacology, 1978
- Dopaminergic supersensitivity after neuroleptics: Time-course and specificityPsychopharmacology, 1978
- Dopamine receptor binding: Differentiation of agonist and antagonist states with 3H-dopamine and 3H-haloperidolLife Sciences, 1975
- Dopamine-Sensitive Adenylyl Cyclase in Human Caudate NucleusArchives of General Psychiatry, 1975
- Serum Prolactin Levels in Unmedicated Schizophrenic PatientsArchives of General Psychiatry, 1974
- Central Dopamine Turnover in Schizophrenic SyndromesArchives of General Psychiatry, 1974
- An Anatomy of Schizophrenia?Archives of General Psychiatry, 1973