Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin release.
Open Access
- 1 February 1980
- Vol. 21 (2), 94-97
- https://doi.org/10.1136/gut.21.2.94
Abstract
Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correlation between these two. The demonstration of calcitonin stimulation of gastric somatostatin release raises the possibility of somatostatin-mediated suppression of gastrin secretion by calcitonin.Keywords
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