GENETIC ORGANIZATION OF THE REGION AROUND UNC-15 (I), A GENE AFFECTING PARAMYOSIN IN CAENORHABDITIS ELEGANS
Open Access
- 1 November 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 96 (3), 639-648
- https://doi.org/10.1093/genetics/96.3.639
Abstract
In the nematode Caenorhabditis elegans mutants in the gene unc-15 (I) affect the muscle protein paramyosin (Waterston, Fishpool and Brenner 1977). We have characterized 20 ethyl methanesulfonate-induced mutations in essential genes closely linked to unc-15. These lethals defined 16 new complementation groups. In the 0.65 map-unit interval around unc-15 defined by dpy-14 and unc-56, seven newly identified genes have been mapped relative to five existing genes. At present, the average distance between genes in this region is approximately 0.05 map units. Two genes, unc-15 and unc-13, are only 0.025 map units apart. Partial fine-structure maps of alleles of these two genes have been constructed. This analysis of unc-15 and genes adjacent to it is the first in a series of genetic and biochemical studies directed towards understanding the control of unc-15 expression.This publication has 8 references indexed in Scilit:
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