GENETIC-CONTROL OF EXPERIMENTAL AUTO-IMMUNE MYASTHENIA-GRAVIS IN MICE .1. LYMPHOCYTE PROLIFERATIVE RESPONSE TO ACETYLCHOLINE-RECEPTOR IS UNDER H-2-LINKED IR GENE-CONTROL

Abstract

To determine the genetic control of experimental autoimmune myasthenia gravis in mice, the proliferative responses of lymph node cells to Torpedo californica acetylcholine receptors (TAR) were tested. Studies with congenic and recombinant inbred strains of mice revealed that T[thymus-derived]-cell responses to TAR are controlled by an H-2-linked Ir gene, mapping in the I-A subregion of mouse major histocompatibility complex.