DNAzymes for sensing, nanobiotechnology and logic gate applications
Top Cited Papers
- 24 April 2008
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 37 (6), 1153-1165
- https://doi.org/10.1039/b718428j
Abstract
Catalytic nucleic acids (DNAzymes or ribozymes) are selected by the systematic evolution of ligands by exponential enrichment process (SELEX). The catalytic functions of DNAzymes or ribozymes allow their use as amplifying labels for the development of optical or electronic sensors. The use of catalytic nucleic acids for amplified biosensing was accomplished by designing aptamer–DNAzyme conjugates that combine recognition units and amplifying readout units as in integrated biosensing materials. Alternatively, “DNA machines” that activate enzyme cascades and yield DNAzymes were tailored, and the systems led to the ultrasensitive detection of DNA. DNAzymes are also used as active components for constructing nanostructures such as aggregated nanoparticles and for the activation of logic gate operations that perform computing.Keywords
This publication has 60 references indexed in Scilit:
- Electronic Aptamer‐Based SensorsAngewandte Chemie International Edition, 2007
- Smart Nanomaterials Inspired by Biology: Dynamic Assembly of Error-Free Nanomaterials in Response to Multiple Chemical and Biological StimuliAccounts of Chemical Research, 2007
- Functional DNA nanotechnology: emerging applications of DNAzymes and aptamersCurrent Opinion in Biotechnology, 2006
- Catalytic Beacons for the Detection of DNA and Telomerase ActivityJournal of the American Chemical Society, 2004
- Lighting Up Biochemiluminescence by the Surface Self‐Assembly of DNA–Hemin ComplexesChemBioChem, 2004
- A DNA Oligonucleotide−Hemin Complex Cleavest-Butyl Hydroperoxide through a Homolytic MechanismInorganic Chemistry, 2001
- The Peroxidase Activity of a Hemin−DNA Oligonucleotide Complex: Free Radical Damage to Specific Guanine Bases of the DNAJournal of the American Chemical Society, 2001
- DNA-enhanced peroxidase activity of a DNA aptamer-hemin complexChemistry & Biology, 1998
- In vitro selection of RNA molecules that bind specific ligandsNature, 1990
- Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA PolymeraseScience, 1990