Neuroblastoma Cell - Oligodendrocyte Interaction Is Mediated by Neural Cell Adhesion Molecules
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Developmental Neuroscience
- Vol. 10 (4), 231-235
- https://doi.org/10.1159/000111973
Abstract
The role of neural cell adhesion molecule (NCAM) in the interaction between neurons and oligodendrocytes was studied using N2A neuroblastoma cells, which express only the 180,000 Mr NCAM and rat oligodendrocytes which express only 120,000 Mr NCAM. Oligodendrocytes bound to neuroblastoma cells, and the binding was inhibited by anti-NCAM, suggesting that NCAM is involved in oligodendrocyte-neuron interaction. The possible role of NCAM in myelination and remyelination is discussed.Keywords
This publication has 9 references indexed in Scilit:
- Myelin-associated glycoprotein, a member of the L2/HNK-1 family of neural cell adhesion molecules, is involved in neuron-oligodendrocyte and oligodendrocyte-oligodendrocyte interaction.The Journal of cell biology, 1987
- C6 glioma cells express modified neural-cell adhesion molecule-like glycoproteinsBrain Research, 1987
- Organization of the neural cell adhesion molecule (N-CAM) gene: alternative exon usage as the basis for different membrane-associated domains.Proceedings of the National Academy of Sciences, 1987
- Oligodendrocyte cell adhesion molecules are related to neural cell adhesion molecule (N-CAM)Journal of Neuroscience, 1986
- Selective expression of the 180-kD component of the neural cell adhesion molecule N-CAM during development.The Journal of cell biology, 1985
- Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule.Proceedings of the National Academy of Sciences, 1983
- Molecular topography of the neural cell adhesion molecule N-CAM: surface orientation and location of sialic acid-rich and binding regions.Proceedings of the National Academy of Sciences, 1983
- Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide.The EMBO Journal, 1982
- Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous systemDevelopmental Biology, 1981