Inhibition of Sterol Biosynthesis in Candida albicans by Imidazole-containing Antifungals

Abstract

A simple procedure for studying sterol biosynthesis in cell-free homogenates of C. albicans is described. The activities of some imidazole-containing antifungals (tioconazole, clotrimazole, econazole, ketoconazole and miconazole) as inhibitors of sterol C-14 demethylation were determined using this technique.