Complementation Studies of Lethal Alleles in the Mouse Causing Deficiencies of Glucose-6-Phosphatase, Tyrosine Aminotransferase, and Serine Dehydratase
- 1 March 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (3), 825-829
- https://doi.org/10.1073/pnas.71.3.825
Abstract
The pleiotropic effects of six radiation-induced lethal alleles at the albino locus in the mouse include deficiencies of various enzymes and of serum proteins. Closely correlated with the biochemical deficiencies are severe ultrastructural abnormalities of endoplasmic reticulum membranes and the Golgi apparatus in liver and kidney cells. Complementation studies led to the distinction of four different complementation groups among the six lethal alleles. The results are compatible with the interpretation that the six lethal alleles represent overlapping deletions of various sizes at and around the albino locus in the mouse, in a region concerned with the control of biochemical and structural differentiation.Keywords
This publication has 7 references indexed in Scilit:
- ULTRASTRUCTURAL BASIS OF BIOCHEMICAL EFFECTS IN A SERIES OF LETHAL ALLELES IN THE MOUSEThe Journal of cell biology, 1973
- Multiple biochemical effects of a series of X-ray induced mutations at the albino locus in the mouseBiochemical Genetics, 1973
- The quinacrine fluorescence karyotype of Mus musculus and demonstration of strain differences in secondary constrictionsCytogenetic and Genome Research, 1971
- Glucose 6-phosphatase deficiency: Mechanisms of genetic control and biochemistryBiochemical Genetics, 1970
- The Developmental Formation of Liver Glucose 6-Phosphatase and Reduced Nicotinamide Adenine Dinucleotide Phosphate Dehydrogenase in Fetal Rats Treated with ThyroxineJournal of Biological Chemistry, 1968
- Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse.Proceedings of the National Academy of Sciences, 1968
- The Assay of Aromatic Amino Acid Transaminations and Keto Acid Oxidation by the Enol Borate-Tautomerase MethodJournal of Biological Chemistry, 1958