Effects of Sulfanilamide, Sulfapyridine, Sulfathiazole and Sulfanilylguanidine upon Colon-Typhoid-Dysentery Group

Abstract

Conclusions In vitro studies on several sulfonamide derivatives indicate sulfathiazole and sodium sulfathiazole to be somewhat more effective than sulfapyridine and distinctly superior to sulfanilamide and to sulfanilylguanidine against the colon-typhoid-dysentery group. Feeding the several compounds in the diet to mice, caused, with a single exception, a significant reduction of the number of coliform organisms normally present in the intestinal excreta. Sulfanilamide, under the conditions of this test, proved to be ineffective in lowering the fecal B. coli count of the animals.