Fluid from the coagulating gland of the guinea pig injected intravenously or intramuscularly produced toxic effects (miosis, urination, defecation, salivation) and death in rabbits, recalling the parasympathicomimetic action of certain drugs. When it was injected into guinea pigs intravenously, it caused urination, defecation, prostration, and death in about one hour. In guinea pigs, the intramuscular injection of this material caused regional clonus. Fluid from the coagulating glands of rats and mice injected into rabbits did not produce a similar effect.