The histopathology of tissues in “resistant” and “susceptible” strains of mice infected with a moderate dose of Mycobacterium lepraemurium
- 1 March 1983
- journal article
- research article
- Published by Wiley in The Journal of Pathology
- Vol. 139 (3), 275-290
- https://doi.org/10.1002/path.1711390305
Abstract
A systematic study by light and electron microscopy of tissues from BALB/c and C57BL/6 mice infected subcutaneously with 107 Mycobacterium lepraemurium organisms was carried out at various times throughout the infection. The relatively resistant C57BL/6 mice had an earlier inflammatory response at the site of the infection than did the susceptible BALB/c mice. The infiltration in the former strain contained fibroblast-like cells and epithelioid cells early on in the infection. Few lymphocytes were observed in both strains throughout the infection. The spread of acid-fast bacilli was slower in the resistant strain (C57BL/6). The findings indicated that the rate of cellular infiltration at the infection site and the nature of the cells in the infiltration may determine the outcome of this infection.This publication has 6 references indexed in Scilit:
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