Stimulation and Retardation of Limb Regeneration by Adenosine 3′,5′-Monophosphate and Related Compounds

Abstract

Limb regeneration in the newt, Notophthalmus viridescens, was retarded by treatment with acetylcholine or imidazole, whereas mitotic activity and regenerative growth were stimulated by cyclic AMP, its dibutyryl derivative, and theophylline. It is proposed that cyclic nucleotides are implicated in amphibian limb regeneration and may be related to the neural factor postulated by others.