Large single daily dose of histamine H2 receptor antagonist for duodenal ulcer. How much and when? A clinical pharmacological study.
Open Access
- 1 May 1987
- Vol. 28 (5), 566-572
- https://doi.org/10.1136/gut.28.5.566
Abstract
The effects of single doses of cimetidine 800, 1200, and 1600 mg, given at 2300 h or 800, and 1600 mg at 1800 h, have been studied in patients with duodenal ulcer disease in symptomatic remission, and compared with cimetidine 400 mg bd (0800 h and 2300 h) and ranitidine 300 mg (given at 1800 h) respectively. A dose related reduction in intragastric acidity was seen. All single nocturnal (2300 h) doses of cimetidine produced anacidity overnight. This was not achieved with dosing at 1800 h although the duration of inhibition of gastric acidity was longer. Inhibition of overnight acid and pepsin outputs were similarly dose and timing related, but inhibition of peptic activity was much less after dosing at 1800 h. Cimetidine 1600 mg and ranitidine 300 mg were similar in their effects.This publication has 18 references indexed in Scilit:
- Mucus degradation by pepsin: comparison of mucolytic activity of human pepsin 1 and pepsin 3: implications in peptic ulceration.Gut, 1986
- NOCTURNAL DOSES OF H2 RECEPTOR ANTAGONISTS FOR DUODENAL ULCERThe Lancet, 1985
- Factors influencing healing of duodenal ulcerDigestive Diseases and Sciences, 1985
- Comparison of cimetidine 800 mg once daily and 400 mg twice daily in acute duodenal ulceration.BMJ, 1984
- Effect of no treatment, cimetidine 1 g/day, cimetidine 2 g/day and cimetidine combined with atropine on nocturnal gastric secretion in cimetidine non-responders.Gut, 1984
- RANITIDINE 150 mg TWICE DAILY VS 300 mg NIGHTLY IN TREATMENT OF DUODENAL ULCERSThe Lancet, 1984
- Single nocturnal dose of an H2 receptor antagonist for the treatment of duodenal ulcer.Gut, 1983
- Exogenous and endogenous acid and pepsins in the pathogenesis of duodenal ulcers in the ratDigestive Diseases and Sciences, 1980
- pH OR HYDROGEN-ION CONCENTRATION IN STATISTICS?The Lancet, 1977
- Effect of cimetidine on 24-hour intragastric acidity in normal subjects.Gut, 1976