The occurrence of diffuse amyloidosis among patients suffering from chronic sepsis, tuberculosis, syphilis and certain malignant diseases has long been recognized, and it should be suspected in the presence of these conditions if hepatic or splenic enlargement or evidences of renal involvement are noted. In the absence of disease ordinarily bearing an etiologic relationship to amyloidosis, however, this condition probably often escapes recognition because it is not suspected. Atypical cases of amyloidosis which may be of obscure origin do occur. Three unusual cases of diffuse amyloidosis are herewith presented. Case 1 has been reported previously,1 and we are including only an abstract of it. REPORT OF CASES Case 1.—History. —A Mexican, aged 38, was admitted to the Mayo Clinic on Jan. 28, 1929, at which time a diagnosis of lymphosarcoma of Hodgkin's type was made. This was confirmed by histologic studies of one of the enlarged cervical nodes. Roentgen