Cephanone: In Vitro Antibacterial Activity and Pharmacology in Normal Human Volunteers
- 1 October 1972
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 2 (4), 250-254
- https://doi.org/10.1128/aac.2.4.250
Abstract
Cephanone, a new 3-heterocyclic-thiomethyl cephalosporin antibiotic, was found to have an antibacterial spectrum similar to that of cephalothin. The compound was active in vitro against a variety of gram-positive and gram-negative bacteria. All strains of Staphylococcus aureus tested were inhibited by concentrations of 6.2 μg or less of cephanone per ml. Beta-hemolytic group A streptococci and pneumococci were exquisitely sensitive. Among strains of Escherichia coli and Klebsiella sp., 83 and 82%, respectively, were inhibited by 3.1 μg or less of cephanone per ml. Excellent serum concentrations of the antibiotic were obtained after parenteral administration. Peak concentrations of 38 and 81.2 μg/ml were achieved in the serum after intramuscular and intravenous doses of 1 g of cephanone, respectively. The serum concentrations of cephanone fell gradually during the 12 hr after administration. Very high concentrations of cephanone were found in the urine.Keywords
This publication has 3 references indexed in Scilit:
- Biological Properties of Three 3-Heterocyclic-Thiomethyl Cephalosporin AntibioticsAntimicrobial Agents and Chemotherapy, 1972
- Cephapirin: Pharmacology in Normal Human VolunteersThe Journal of Clinical Pharmacology and New Drugs, 1972
- Cephapirin: in vitro antibacterial spectrum.1971