Radioprotective Property of the Ethanolic Extract of Piper betel Leaf
Open Access
- 1 January 2005
- journal article
- Published by Oxford University Press (OUP) in Journal of Radiation Research
- Vol. 46 (2), 165-171
- https://doi.org/10.1269/jrr.46.165
Abstract
The radioprotective activity of Piper betel ethanolic extract (PE) has been studied using rat liver mitochondria and pBR 322 plasmid DNA as two model in vitro systems. The extract effectively prevented γ-ray induced lipid peroxidation as assessed by measuring thiobarbituric acid reactive substrates, lipid hydroperoxide and conjugated diene. Likewise, it prevented radiation-induced DNA strand breaks in a concentration dependent manner. The radioprotective activity of PE could be attributed to its hydroxyl and superoxide radicals scavenging property along with its lymphoproliferative activity. The radical scavenging capacity of PE was primarily due to its constituent phenolics, which were isolated and identified as chevibetol and allyl pyrocatechol.Keywords
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