AN ATTEMPT TO CONDITION GASTRIC SECRETION TO HISTAMIN

Abstract

Using histamin as a type of drug producing an effect through peripheral instead of central action, the authors tried to condition gastric secretion produced by the inj. of histamin in dogs with Pavlov pouches. Although a good unconditioned secretion was obtained, after as many as 75 injs. at daily intervals in 3 dogs, there was no evidence of a conditioned gastric secretion to the inj. of normal saline. These expts. together with the authors'' failure to condition adrenalin hyperglycemia are evidence for the necessity of a central excitatory state for the formation of the conditioned reflex.