The breast cancer susceptibility gene, BRCA2 : at the crossroads between DNA replication and recombination?
Open Access
- 29 February 2000
- journal article
- review article
- Published by The Royal Society in Philosophical Transactions Of The Royal Society B-Biological Sciences
- Vol. 355 (1394), 191-198
- https://doi.org/10.1098/rstb.2000.0558
Abstract
The identification and cloning of the familial breast cancer susceptibility gene, BRCA2 , has excited much interest in its biological functions. Here, evidence is reviewed that the protein encoded by BRCA2 has an essential role in DNA repair through its association with mRad51, a mammalian homologue of bacterial and yeast proteins involved in homologous recombination. A model is proposed that the critical requirement for BRACA2 in cell division and the maintenance of chromosome stability stems from its participation in recombinational processes essential for DNA replication.Keywords
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