Beyond αβ/γδ lineage commitment: TCR signal strength regulates γδ T cell maturation and effector fate
- 31 August 2010
- journal article
- review article
- Published by Elsevier BV in Seminars in Immunology
- Vol. 22 (4), 247-251
- https://doi.org/10.1016/j.smim.2010.04.006
Abstract
No abstract availableKeywords
This publication has 56 references indexed in Scilit:
- Roles of the Src Tyrosine Kinases Lck and Fyn in Regulating γδTCR Signal StrengthPLOS ONE, 2010
- Cutting Edge: Spontaneous Development of IL-17–Producing γδ T Cells in the Thymus Occurs via a TGF-β1–Dependent MechanismPublished by The American Association of Immunologists ,2010
- Marked Induction of the Helix-Loop-Helix Protein Id3 Promotes the γδ T Cell Fate and Renders Their Functional Maturation Notch IndependentImmunity, 2009
- The SoxD transcription factors – Sox5, Sox6, and Sox13 – are key cell fate modulatorsThe International Journal of Biochemistry & Cell Biology, 2009
- TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversityProceedings of the National Academy of Sciences, 2009
- Enhanced development of CD4+ γδ T cells in the absence of Itk results in elevated IgE productionBlood, 2009
- Tec kinase Itk in γδT cells is pivotal for controlling IgE production in vivoProceedings of the National Academy of Sciences, 2009
- Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γImmunity, 2008
- T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysisThe Journal of Experimental Medicine, 2008
- Lck Regulates the Threshold of Activation in Primary T Cells, While both Lck and Fyn Contribute to the Magnitude of the Extracellular Signal-Related Kinase ResponseMolecular and Cellular Biology, 2006