Determination of Lymphocyte Turnover by Continuous Infusion of H3 Thymidine
Open Access
- 1 February 1962
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 19 (2), 236-242
- https://doi.org/10.1182/blood.v19.2.236.236
Abstract
The use of an osmotic pump for continuous infusion of H3 thymidine in rats is described. Estimates of turnover times of cells in the peripheral blood are 4 days for granulocytes, 60 days for large lymphocytes and in excess of 100 days for small lymphocytes. These turnover times include initial delay in release or maturation after the last mitosis in the marrow or nodes, and any time spent outside the circulation prior to final disappearance of a given cell from the peripheral blood. The data exclude reutilization as an explanation for the observed longevity of lymphocytes.Keywords
This publication has 3 references indexed in Scilit:
- THE EFFECT OF THE CONTINUOUS RE-INFUSION OF LYMPH AND LYMPHOCYTES ON THE OUTPUT OF LYMPHOCYTES FROM THE THORACIC DUCT OF UNANAESTHETIZED RATS1957
- THE QUANTITATIVE STUDY OF THE LEUKOCYTESAnnals of the New York Academy of Sciences, 1955
- The relative rates of formation of new leukocytes in patients with acute and chronic leukemias.Measured by the uptake of radioactive phosphorus in the isolated desoxyribosenucleic acidCancer, 1952