Synthesis of 2-Acetamido-1,5-imino-1,2,5-trideoxy-d-mannitol and of 2-Acetamido-1,5-imino-1,2,5-trideoxy-d-glucitol, a Potent and Specific Inhibitor of a Number of β-N-Acetylglucosaminidases
- 5 July 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 15 (7), 1051-1054
- https://doi.org/10.1246/cl.1986.1051
Abstract
The stereochemical outcome of the azide displacement of triflates derived from a piperidin-3-ol depends on the protecting group on the ring nitrogen and allows the synthesis of 2-acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol (a potent and specific inhibitor of a number of β-N-acetylglucosaminidases) and of 2-acetamido-1,5-imino-1,2,5-trideoxy-D-mannitol.Keywords
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