Increased exercise tolerance with nitrates in beta-blockaded patients with angina.
- 27 August 1977
- Vol. 2 (6086), 550-552
- https://doi.org/10.1136/bmj.2.6086.550
Abstract
In 14 beta-blockaded anginal subjects, 10 of whom had poor left ventricular function, sublingual isosorbide dinitrate significantly increased maximal exercise capacity on a standardized multistage treadmill test. This was associated with changes in heart rate and blood pressure suggestive of a fall in left ventricular work. The effect of isosorbide lasts for at least two hours and when taken before exercise may be a useful addition to beta-blockade in patients with angina.Keywords
This publication has 12 references indexed in Scilit:
- Hemodynamic Effects of Isosorbide Dinitrate vs Nitroglycerin in Patients with Unstable AnginaChest, 1976
- Reassessment of failed beta-blocker treatment in angina pectoris by peak-exercise heart rate measurements.BMJ, 1975
- Comparative hemodynamic effects of placebo and oral isosorbide dinitrate in patients with significant coronary artery diseaseAmerican Heart Journal, 1975
- Improvement in left ventricular wall motion following nitroglycerin.Circulation, 1975
- Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular diseaseAmerican Heart Journal, 1973
- Effect of Ischemia and Antianginal Drugs on the Distribution of Radioactive Microspheres in the Canine Left VentricleCirculation Research, 1971
- The Effect of Propranolol in the Long-Term Treatment of Angina PectorisArchives of Internal Medicine, 1969
- Hemodynamic Effects of Nitroglycerin, Propranolol, and Their Combination in Coronary Heart DiseaseCirculation, 1969
- Use of Propranolol in Angina PectorisBMJ, 1965
- Double-blind Trail to Propranolol (Inderal) in Angina PectorisBMJ, 1965