Daily smoking and use of alcohol have a many-fold influence on lipid metabolism. The relations between HDL-cholesterol, alcohol use and smoking are well known. During recent years, the influence of smoking on postprandial lipid and glucose metabolism, and on insulin sensitivity in particular, has gained increasing attention. In addition, new data have emerged about the oxidative properties of alcohol use and smoking. As life habits tend to show clustering, isolating mechanisms responsible for the lipid changes induced by smoking or alcohol per se is difficult and is one factor causing contradiction in this study area.