Isle of Wight disease is, as we have seen, primarily a disease of the respiratory system, in which the organism remains localised throughout the entire course of the attack. The effects are, however, far-reaching, and are registered in the disordered functioning of several organs, and in visible pathological changes in some of them. The parasitic invasion has two aspects. We have, in the first place, to consider the active injury wrought upon the host by a parasite developing and living at the expense of its body fluids. With this aspect of the question may be coupled the possibility of a definite toxic action on the part of the parasite. In the second place, we have to consider the passive rôle of the mites in hindering or inhibiting the normal functions of the infected organs. Before proceeding to consider the various pathological conditions, a few words on the distribution of the parasite within the host is called for.